| 摘要 |
<p>Nicardipine hydrochloride, i.e. 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3-methyl ester-5- beta -(N-benzyl-N-methylamino)ethyl ester, is prepared in a short time at a high yield by reacting, in a non-aqueous system, m-nitrobenzaldehyde or another compound of formula (1) <CHEM> wherein either R1 and R2 are taken together and represent =O or =N-lower alkyl, or R1 represents -O-, R2 represents -NH-, and R1 and R2 are linked via C2-4 straight or branched-chain alkylene to form a saturated heterocyclic ring which may be substituted, simultaneously or sequentially, in either order, with methyl 3-aminocrotonate and (N-methyl-N-benzylamino)ethyl 3-aminocrotonate.</p> |
