PHYSIOLOGICALLY ACTIVE PEPTIDES HAVING BRONCHODILATIVE AND HYPOTENSIVE ACTIVITY

摘要

Novel peptides are disclosed having the structure: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-X-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile Leu-Asn-Gly-Y wherein X is Met or Leu; and Y is OH, Lys-OH, Arg-OH, LysArg-OH, or Lys-NH2 when X is Met, or Y is Lys-NH2, Lys-OH, or Lys-Arg-OH when X is Leu. The peptides exhibit bronchodilative activity and hypotensive activity.