AROMATIC AMINE COMPOUND, ITS PREPARATION AND DRUG CONTAINING SAME

摘要

The invention relates to compounds of formula …… in which: … …  - m is an integer from 1 to 3; …  - Ar and Ar' represent, independently, a thienyl group, a substituted or unsubstituted phenyl group; an imidazolyl group; it also being possible for Ar' to be a benzothienyl group, unsubstituted or substituted with a halogen; a naphthyl group, unsubstituted or substituted with a halogen; a biphenyl group; an unsubstituted or substituted indolyl; …  - X represents hydrogen; …  - X' represents hydrogen or a hydroxyl group, or is joined to X'' below to form a carbon-carbon bond;… . or alternatively X and X' together form an oxo group or a dialkylaminoalkyloxyimino group of formula =N-O-(CH2)p-Am where p is 2 or 3 and Am is a dialkylamino group; …  - Y represents a nitrogen atom or a group C(X'') where X'' is hydrogen, or, with X', forms a carbon-carbon bond; …  - Q represents hydrogen, a C1-C4 alkyl group or an aminoalkyl group of formula -(CH2)q-Am', where q is 2 or 3 and Am' is a piperidino, 4-benzylpiperidino or dialkylamino group; …  - R represents hydrogen, a methyl group or a group (CH2)n-L, where n is an integer from 2 to 6 and L is hydrogen or an amino group; …  - T represents a group chosen from …… W being an oxygen or sulphur atom, and …  - Z represents either hydrogen, or M or OM when T represents the group …… or M when T represents the group …… M represents hydrogen or a linear or branched alkyl; an unsubstituted or substituted phenylalkyl; a pyridylalkyl; a naphthylalkyl; a pyridylthioalkyl; a styryl; a (1-methyl)-2-imidazolylthioalkyl; a 1-oxo-3-phenylindan-2-yl; an unsubstituted or substituted aromatic or heteroaromatic group; … or one of their salts with inorganic or organic acids. …Application: neurokinin receptor antagonists.