| 摘要 |
Process for solubilising peptide in a water-immiscible organic solvent, consisting in bonding a lipophilic group to the terminal carboxylic group of the said peptide via an amide or ester bond; this lipophilic group is characterised in that when it is bonded to L-serine a molecule is obtained whose solubility in water at 25 DEG C is lower than 30 g/litre. This lipophilic group is chemically defined and nonpolymeric. The invention also relates to a process for the synthesis of optionally protected peptides, in liquid medium, characterised in that it starts with an amino acid or a peptide solubilised in organic medium by a lipophilic A-L group bonded to the carboxylic functional group of the starting amino acid or peptide and in that the amino acids or the peptides to be condensed, which are activated on their acidic functional group and protected on their amine functional group and optionally on their side chain, are added. The peptides originating from the synthesis are optionally employed for the synthesis of medications, vaccines and agri-foodstuffs or plant protection products. |
