发明名称 |
MONONUCLEAR LEUKOCYTE DIRECTED ENDOTHELIAL ADHESION MOLECULE ASSOCIATED WITH ATHEROSCLEROSIS |
摘要 |
The invention relates to novel endothelial cell-leukocyte adhesion molecules designated ATHERO-ELAM. ATHERO-ELAM molecules are expressed on cultured endothelial cells stimulated with bacterial LPS and selectively mediate the binding of monocytes to the endothelial cells. Monoclonal antibodies specific for ATHERO-ELAM bind to vascular endothelial cells involved in early atherosclerotic lesions, but not to vascular endothelial cells from uninvolved arterial tissue. ATHERO-ELAM and antibodies directed to ATHERO-ELAM may be used in identifying early atherosclerotic lesions and in treating and preventing atherosclerosis. |
申请公布号 |
WO9113085(A1) |
申请公布日期 |
1991.09.05 |
申请号 |
WO1991US01400 |
申请日期 |
1991.02.28 |
申请人 |
BRIGHAM AND WOMEN'S HOSPITAL |
发明人 |
GIMBRONE, MICHAEL, A., JR.;CYBULSKY, MYRON, I.;COLLINS, TUCKER |
分类号 |
A61K39/00;A61K38/00;A61K39/395;A61K45/00;A61K49/00;A61P9/10;C07K14/00;C07K14/435;C07K14/705;C07K16/00;C07K16/28;C12N15/02;C12P21/00;C12P21/08;C12R1/91;G01N33/50;G01N33/53;G01N33/68 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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