Milbemycin ether derivatives, their preparation and their anthelmintic uses.

摘要

A process of formula (I): <CHEM> [in which: R<1> is hydrogen, halogen, cyano, nitro, optionally substituted alkyl, alkoxy, alkoxyalkoxy, or a group of formula: <MATH> <CHEM> in which: m is 1 or 2; n is 0, 1 or 2; R<6> is hydrogen or a variety of organic groups; R<7> is alkyl, cycloalkyl, or aralkyl; R<9> is hydrogen or alkyl; R<1><1> is any of R<6>, or cyano, nitro, -COOR<7> or -COR<6>; Y is an oxygen or a sulphur; Z is -COOR<7>, -COR<6> or -SO2R<6>; A is a group of formula: -CHR<2>-CHR<3>-CHR<4>- -CR<2>=CR<3>-CHR<4>- or <CHEM> in which R<2>, R<3> and R<4> are hydrogen, halogen, alkyl or alkoxy; R<5> is methyl, ethyl, isopropyl or sec-butyl; and X is hydroxy, optionally substituted alkanoyloxy or hydroxyimino] and salts and esters thereof have valuable anthelmintic, acaricidal and insecticidal activities. Methods of preparing the compounds are also provided.