发明名称 |
Compounds containing 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl and catalytic metal complexes thereof. |
摘要 |
<p>A phosphine compound 2,2 min -bis[di-(3,5-dialkylphenyl) phosphino]-1,1 min -binaphthyl is represented by the formula <CHEM> wherein R represents a C1-4 alkyl group. Synthesis is by reacting 2,2 min -dibromo-1,1 min -binaphthyl (see JP-A-55-61937) with Mg and reacting the resultant Grignard reagent with a bis(3,5-dialkyphenyl phosphonyl chloride;the resulting racemic phosphoryl binaphthyl is dissolved and crystals thereof recrystallised to purify them; (+)- and (-)- forms of the free phosphine oxide are obtained and reduced with trichlorosilane to provide the (+)- or (-)- isomers of the novel compound; or the racemate can be produced. The compound can be reacted with a compound of a transition element such as rhodium, palladium or ruthenium as a ligand to make a complex thereof which is useful as a catalyst in an asymmetric synthesis reaction, e.g. asymmetric hydrogenation of a beta -keto ester, to give a product of high optical purity in high yield.</p> |
申请公布号 |
EP0444930(A1) |
申请公布日期 |
1991.09.04 |
申请号 |
EP19910301644 |
申请日期 |
1991.02.28 |
申请人 |
TAKASAGO INTERNATIONAL CORPORATION |
发明人 |
ISHIZAKI, TAKEROU;HORI, YOJI;KUMOBAYASHI, HIDENORI |
分类号 |
B01J31/22;B01J31/24;C07B53/00;C07B61/00;C07F9/50;C07F15/00 |
主分类号 |
B01J31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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