摘要 |
The invention relates to new oxadiazole-alkyl-purine-derivatives of the general Formula I and pharmaceutically acceptable salts thereof (wherein A stands for C1-4 alkylene and R1 represents C1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C5-6 cycloalkyl or aminoalkyl of the general Formula -(CH2)n-NR2R3 in which group n is an integral 1-3; R2 and R3 each stand for hydrogen or C1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; or R1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzyl The compounds of the general Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents. |
申请人 |
CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. |
发明人 |
KORBONITS, DEZSOE;MINKER, EMIL;VARGAI, ZOLTAN;HEJA, GERGELY;KOVACS, GABOR;GOTTSEGEN, AGNES;ANTUS, SANDOR;VIRAG, SANDOR;BOLEHOVSZKY, ANDREA;MARTON, JENOE;MARMAROSI, KATALIN;DEBRECZENI, LORAND;TARDOS, LAESZLOE;KOERMOCZY, PETER;GERGELY, VERA;HORVATH, GABOR |