发明名称 |
INCLUSION COMPLEXES WITH SILYBININ,THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
摘要 |
The invention relates to novel inclusion complexes of Silybinin with a cyclodextrin selected from the group consisting of alpha -, beta - and gamma -cyclodextrin and a suitable derivative thereof and to the method for the preparation thereof. The novel inclusion complexes of Silybinin showed a highly improved bioavailability in comparison to Silybinin which makes them particularly interesting in the treatment of various hepatotoxic conditions. |
申请公布号 |
ZA9008069(B) |
申请公布日期 |
1991.08.28 |
申请号 |
ZA19900008069 |
申请日期 |
1990.10.09 |
申请人 |
MADAUS A.G. ISTITUTO BIOCHIMICO ITALIANO |
发明人 |
UMBERTO VALCAVI;VINCENZO MONTEROSSO;ROBERTO CAPONI;ENRICO BOSONE;WILFRIED WACHTER;JOZSEF SZETIL |
分类号 |
C07D407/04;A61K31/00;A61K31/335;A61K31/35;A61K31/715;A61K47/40;A61P1/16;C08B;C08B37/00;C08B37/16 |
主分类号 |
C07D407/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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