7-DITHIOALKYLAMINO-MITOSANE ANALOGS

摘要

This invention refers to 7-amino mitosane analogs (mitomycin C) in which the 7-amino group bears an organic substituent incorporating a disulfide group and to a novel thiol exchange process for producing these compounds. The compounds are inhibitors of experimental animal tumors. Some of the novel compounds produced by this process are represented by the structural formula: Formula IX