NOVEL PEPTIDE SUBSTRATES, METHOD OF PREPARATION AND USE IN C PROTEIN DETERMINATION

摘要

Peptide compounds, as novel industrial products, chosen from the series consisting of (i) tripeptides having the formula: Y-A1-A2-A3-R in which Y represents H or a suitable group blocking the N-terminated end, A1 represents an amino-acid group chosen from the series consisting of the groups (2-oxo-thiazolidin-4-yl)carbonyl (THC), (2-oxo-tetrahydro-1,3-thiazin-5-yl)carbonyl (TZC), thiazolidine-4-carbonyl (ATC) and tetrahydro-1,3-thiazin-5-yl)carbonyl (AZC), A2 represents an amino-acid group chosen from the series comprising the groups Pro, 3Hyp and 4Hyp where the 3Hyp and 4Hyp OH lateral group is capable of being protected by a protecting ether or ester group, A3 represents an amino-acid group chosen from the series comprising the groups Arg and Lys and R represents a labelling means; and (ii) their addition salts. These novel compounds are useful as substrates for C protein determination.