摘要 |
<p>The invention relates to a process for acylating compounds. The process comprises reacting a compound such as an alcohol, a thiol, an amino compound or other compounds containing functional groups, with an acyl halide (preferably an acyl chloride) to form the desired product. The reaction is carried out in alkaline conditions in a multi-phase system comprising a first liquid phase containing the acylatable substrate and a second non-aqueous liquid phase containing the acyl halide. The first and second phases are preferably aqueous polar and non-aqueous non-polar liquids, respectively. The two phases are at least partially immiscible with each other so that the rate of contact between the reactants is controlled and the hydrolysis of the acyl halide is reduced. The two phases are contacted for a time sufficient to bring about the acylation reaction and then the acylated product is separated from the reaction mixture. The process significantly increases the yield of the reaction and reduces the quantities of by-products compared with similar reactions carried out in a single phase system.</p> |