| 摘要 |
A process for the preparation of optically active amino acid amide whereby a mixture of the L-amino and D-amino acid amides in the presence of 0.5-4 equivalents of an aldehyde, relative to the quantity of amino acid amide, in the presence of a solvent and water, is converted in whole or in part by means of an optically active carboxylic acid into a salt of the amino acid amide and the carboxylic acid, and a portion mainly consisting of one of the diastereoisomers of that salt is separated from the reaction mixture obtained. Instead of a mixture of L-amino and D-amino acid amides it is also possible to use a mixture of the Schiff bases of an amino acid amide and an aldehyde, in which case it is not necessary to add extra aldehyde, and the required quantity of water amounts to at least 1 equivalent relative to the quantity of Schiff base. With this process a high yield of optically active amino acid or the corresponding amino acid is rapidly obtained.
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