ISOQUINOLINE DERIVATIVES, THEIR PREPARATION, THEIR USE

摘要

Compounds of formula I (I) wherein R1 is hydrogen or C1-4alkyl; R2 is hydrogen and R3 is hydrogen or C1-4alkyl, or R2 and R3 together represent an additional bond as indicated by the dotted line; R4 is hydrogen, C1-4alkyl or phenyl; R5 is methoxy or ethoxy; R6 is hydrogen, hydroxy, C1-4alkoxy, hydroxy-(C2-4alkoxy) or (C1-4alkoxy)-(C2-4alkoxy); R7 and R8 are each independently C1-4alkoxy or (C1-4alkoxy)-(C2-4alkoxy); and R9 is hydrogen or halogen, in free form or pharmaceutically acceptable salt form, have pharmaceutical utility, in particular as bronchodilators, eosinophil accumulation and/or activation inhibiting agents and in the treatment of prophylactic treatment of obstructive or inflammatory airways diseases.