| 摘要 |
2075988 9112230 PCTABS00006 The present invention relates to novel nitric acid esters of cyclohexanol derivatives of formula (I) in which A is a valency line or a C1-C6 alkylene chain and B is the group -NR1-CO-Z, -NR1-SO2-Z or -CO-NR2-Z, where R1 is hydrogen or a C1-C6-alkyl group, R2 is hydrogen, a hydroxy, hydroxy-C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkyl, C2-C6-alkenyl or C2C6-alkinyl group and Z is hydrogen, a C1-C6-alkyl, C2-C6-alkenyl or C2C6-alkinyl group, which may be substituted once or several times by a hydroxy, C1-C6-alkylcarbonyloxy, C1-C6-alkoxy, halogen, cyano, carboxy, C1-C6-alkoxycarbonyl, -CO-NR3R4, mercapto, C1-C6-alkylcarbonyl mercapto group, or Z is a C3-C6-cycloalkyl group or a pyridine, N-oxypyridine, tetrazolyl or pyrrolidinone ring, or Z together with R2 and the nitrogen atom to which Z and R2 are bonded, form a heterocyclic ring which may additionally contain an oxygen, sulphur or nitrogen atom, whereby the heterocyclic ring with an additional nitrogen atom may be acylated, possibly on the nitrogen atom, by a C1-C6-alkylcarbonyl group, and if B is a -NR1-CO-Z- group, Z may also be a C1-C6-alkoxy group, or if Z is a C1-C6-alkyl or C2-C6-alkenyl group substituted by a mercapto, C1-C6-alkylmercapto or C1-C6-alkylcarbonyl mercapto, the C1-C6-alkyl or C2-C6-alkenyl group may be additionally substituted by the NR4/R5 or a C1-C4-alkylcarbonyl group and R3 and R4 may be the same or different and mutually independently hydrogen, a C1-C6-alkyl group or R3 and R4 together with the nitrogen atom to which they are bonded form a heterocyclic ring, their optically active forms and physiological permissible salts, and medicaments containing these compounds. The invention also concerns processes for producing compounds of formula (I) and novel intermediate products.
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