| 摘要 |
<p>NEW MATERIAL:Compounds of the formula (RCO is 10-25C acyl). EXAMPLE:0-(1-nonadecanoyl-sn-glycero-3-phospho)-N-(9- fluorenylmethyloxycarbonyl)-L-serine 9-fluorenylmethyl ester. USE:An inhibitor for Na<+>, Ka<+>-ATP ase. PREPARATION: From a glycerol derivative and a serine derivative, a phosphite ester is synthesized using the phosphomonochloromonoamidite method and the resultant phosphite ester is then treated with hydrogen peroxide to obtain a phosphoric diester. Methyl groups as protective groups for phosphoric acid and isopropylidene groups as protective groups for glycerol are eliminated therefrom and the resultant compound is subjected to condensation with an anhydride of a mixed acid prepared from various kinds of fatty acids and isobutyl chlorocarbonate, followed by elimination of protective groups for serines in the obtained condensate.</p> |
