| 摘要 |
2-Alkyl-, 2-alkenyl- and 2-alkynyl-2,3-dihydro-2- (1H-azolyl(C1-C2)alkyl)benzo¢b!thiophenes especially 2-alkyl-, 2-alkenyl- and 2-alkynyl-2,3-dihydro-3-hydroxy-2-(1H-1-imidazolylmethyl)-4-, 5-, 6- and 7-halobenzo-¢b!thiophenes and related derivatives having antifungal activity are disclosed. Pharmaceutical compositions comprising compounds of the invention and their use in treating fungal infections in susceptible hosts such as humans are also disclosed. These compounds have the following formula wherein X is halogen or an organic radical such as (lower)alkyl, Y is substituted or unsubstituted imidazolyl or 1,2,4-triazolyl or phenyl(lower)alkyl, R, and R2 are hydrogen or an organic radical such as (lower)alkyl, R3 is an organic radical such as an alkynyl, n is 1 or 2, m is 1, 2, 3 or 4. |
