Use of naphth:oxazine derivs.

摘要

The use of naphthoxazines of formula (I) in pharmaceutical compsns. for the treatment of conditions associated with cerebral ischaemia, e.g. stroke, is new. R1 and R2 independently are H or 1-4C alkyl. R3 = OH or 1-4C alkoxy. R4 = 1-4C alkylthio, 1-4C alkylsulphoxide, 1-4C alkylsulphone, Ckl, Br, I or CF3. Also claimed is (-)-(4aR,10aR)-3,4,4a,5,10,10a-hexahydro-6-methoxy-4-methyl-9-methylth io-2H-naphth(2,3-b)-1,4-oxazine hydrogen malonate, its use in pharmaceutical compsns., and a process for its prodn. which includes the step of reacting the corresponding free base (II) with malonic acid.