INHIBITION OF TRANSCRIPTION BY DOUBLE-STRANDED OLIGONUCLEOTIDES

摘要

The present invention relates to novel methods for controlling gene expression in which double stranded oligonucleotides are used to inhibit the interaction of transcriptional factors with transcriptional control elements in DNA. The methods of the invention are particularly useful in selectively inhibiting transcription of viral genes and oncogenes, and may be used in the treatment of a variety of viral diseases. In preferred embodiments of the invention, nucleosides are joined by phosphorothioate linkage.