PREPARATION AND USE OF GENE BANKS OF SYNTHETIC HUMAN ANTIBODIES (SYNTHETIC HUMAN-ANTIBODY LIBRARIES)

摘要

Synthetic human antibody libraries are constructed by'generation of random sequences for the hypervariable regions under the restrictions (a) or (e), batch A or batch B according to Table 1 and subsequent insertion into an expression vector' (sic). Synthetic human antibody libraries can be produced by using almost randomly synthesised oligonucleotides coding for each of the three hypervariable regions in the variable parts of the heavy and light chains (regions CDR1, CDR2 and CDR3).