INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS -1 INFECTIVITY IN HUMAN CELLS

摘要

Methods are disclosed for inhibiting the infectivity of HIV-1 in human cells. The methods comprise contacting human cells infected with HIV-1, with certain quinolinyl and acridinyl derivatives, including amodiaquin, chloroquine, hydroxychloroquine, primoquine, quinacrine and compounds having formula (I), wherein R<1> and R<2> are each hydrogen, or join to form a cyclic structure of formula (II); and R<3> and R<4>, same or different, are hydrogen, C1-C8 lower alkyl or hydroxy substituted C1-C8 lower alkyl, and the pharmaceutically acceptable salts thereof.