发明名称 |
MOLECULES WITH ANTIBODY COMBINING SITES THAT CATALYSE HYDROLYSIS REACTIONS |
摘要 |
An antibody molecule or molecule containing antibody combining site portions (catalytic molecule) that catalytically hydrolyzes a preselected carboxylic acid amide or ester bond of a reactant ligand, methods of making and using the catalytic molecule, and cells that produce those molecules are disclosed. The catalytic molecules bind to a reactant ligand containing the bond to be hydrolyzed and also to a haptenic ligand. The haptenic ligand is structurally analogous to the reactant ligand and contains a tetrahedral carbon atom that is bonded to a hydroxyl group and to a saturated carbon atom at a position in the haptenic ligand that corresponds to position of the carbonyl group and its bonded heteroatom of the reactant ligand. The haptenic ligand also contains a group that bears an ionic charge in aqueous solution at physiological pH values that is not present at a corresponding position of the reactant ligand. The ionic charge-bearing group is located in the hapten within 7 ANGSTROM ngstroms of the tetrahedral carbon atom. |
申请公布号 |
WO9111512(A1) |
申请公布日期 |
1991.08.08 |
申请号 |
WO1991US00507 |
申请日期 |
1991.01.24 |
申请人 |
SCRIPPS CLINIC AND RESEARCH FOUNDATION |
发明人 |
JANDA, KIM |
分类号 |
C07K14/00;C07C205/43;C07C205/44;C07C215/32;C07C219/34;C07C223/06;C07C229/54;C07C233/25;C07D207/46;C07D213/30;C07D213/38;C07D213/56;C07D317/16;C07D317/28;C07D401/12;C07K16/00;C07K16/44;C12N5/10;C12N9/00;C12N9/18;C12N9/50;C12N15/02;C12P21/08;C12R1/91 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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