| 摘要 |
NEW MATERIAL:The dibenzo[a,d]cycloheptene derivative of formula I [R<1> is H, halogen, alkyl or alkoxy; R<2> is OH or alkoxy; R<3> is H or alkyl; A is group of formula II [n is 1 or 2; R<4> is H or alkyl; R<5> is H, 5 or 6-membered cycloamino, -OCOR<6> (R<6> is alkyl) or -NH(CH2)n-R<7> (n is 0 or 1; R<7> is OH or hydroxycarbonyl)] or 5 or 6-membered cycloamino]. EXAMPLE:3-Methoxy-10,11-dihydro-5-oxo-5H-dibenzo[a,d]cycloheptene-2-ac etic acid. USE:A drug having anti-inflammatory, analgesic and antithrombogenic actions. PREPARATION:The compound of formula I can be produced e.g. by using the compound of formula III as a raw material and esterifying or amidating the compound. |
