| 摘要 |
Compounds of the formula <IMAGE> in which R1 is H or alkyl of 1 to 20 carbons, CO-R1* CO-O-R1* CO-NH-R1* or PO(OR1*)2 or PO(OR1*)R1* where R1* independently is H, alkyl of 1 to 20 carbons, phenyl, or substituted phenyl; X is O, S, SO-, SO2, NH-, or NR2 where R2 is phenyl, substituted phenyl or alkyl of 1 to 20 carbons, and Y is alkyl having at least 6 carbon atoms, arylalkyl, aryl, substituted aryl, substituted arylalkyl, alkenyl containing one or more olephinic bonds and at least 6 carbon atoms, CO-R3, CO-OR3, CONHR3, SO2R3, SO2NHR3 where R3 is aryl, substituted aryl, substituted arylalkyl, alkyl, alkenyl containing one or more olephinic bonds, further Y is (CH2)n-O-R4, or (CH2)n-O-(CH2)m-O-R4, where n, and m, are integers and are independently 1 to 25 and R4 is phenyl, substituted phenyl or alkyl of one to 20 carbons, still further Y is PO(OH)2, PO(OH)OR5, PO(OH)R5 PO(OR5)2, where R5 is independently phenyl, substituted phenyl, alkyl or 1 to 20 carbons or R5 is (CH2)n-N(R5*)3 where R5* is alkyl of 1 to 20 carbons, or Y is NH-R6 where R6 is phenyl, substituted phenyl or alkyl of at least 6 carbon atoms with the proviso that when X is O, S, then Y is not NH-R6, and with the further proviso that when X is SO or SO2 then Y is not SO2R3 or SO2NHR3, are disclosed. The compounds possess anti-inflammatory activity.
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