发明名称 |
Processes for the treatment of vascular disease |
摘要 |
Disclosed herein are improved processes for preparing variant human t-PA proteins exhibiting improved pharmacokinetic properties relative to natural t-PA. One such illustrated variant, devoid of amino acids corresponding to amino acids 1 through 44 of natural t-PA, is shown to exhibit a plasma half-life of greater than about 15 times the plasma half-life to natural t-PA, as well as a clearance rate of less than about 1/10 the clearance rate of natural t-PA. Also disclosed are improved processes for treating vascular disease employing pharmaceutical compositions which incorporate therapeutically effective amounts of such t-PA variants with pharmaceutically acceptable diluents or excipients.
|
申请公布号 |
US5037646(A) |
申请公布日期 |
1991.08.06 |
申请号 |
US19900539987 |
申请日期 |
1990.06.18 |
申请人 |
GENENTECH, INC. |
发明人 |
HIGGINS, DEBORAH L.;HOLMES, WILLIAM E.;HOTCHKISS, ADAIR J. |
分类号 |
C12N9/72;C12N15/58 |
主分类号 |
C12N9/72 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|