| 摘要 |
PURPOSE:To prepare a filler for liquid chromatography having an excellent performance by polymerizing a monomer having a functional group capable of forming a carboxyl group by hydrolytic reaction on the surface parts of hydrophobic crosslinked polymer particles to coat the particles in specific thickness and hydrolyzing the surfaces of the coated particles. CONSTITUTION:As the material of hydropholic crosslinked polymer particles, a polymer obtained by polymerizing a hydrophobic crosslinkable monomer or a copolymer of the hydrophobic crosslinkable monomer and a hydrophobic non-crosslinkable monomer is designated. Therefore, the monomer becoming the material is one having no functional group capable of being chemically reacted under a hydrolytic reaction condition. Further, this hydrophobic crosslinked polymer is the homopolymer of the hydrophobic crosslinkable monomer or a copolymer consisting of two or more kinds of crosslinkable monomers. This monomer is polymerized on the surface of the hydrophobic crosslinked polymer to coat the polymer but the average thickness thereof is 10 - 300 Angstrom and the surfaces of the coated polymer particles are hydrolyzed to be coated with a polymer having a carboxyl group. |
