| 摘要 |
A N-[ omega -(thiazol-4 or 5-yl)alkyl]isourea, isothiourea of a guanidine derivative with formula (II) and a N-( omega -substituted alkyl)-N'-substituted-N''-[ omega -(thiazol-4 or 5-yl)alkyl]-guanidine with formula (III), a process for the preparation of said compounds by ring closure of a 2-bromo- omega -phthalimidoalkanal, or of a 3-bromo or 1-bromo omega -phthalimidoalkan-2-one with thioformamide, an alkylthioamide or thiourea followed by hydrazinolysis or hydrolysis of the resulting phthalimido derivates and medicaments containing said derivatives with formulas (II) and (III) and use of said medicaments for the treatment of congestive heart diseases or for the treatment of allergic disorders. |
