发明名称 |
Ganglioside derivatives and their use as medicaments. |
摘要 |
<p>The invention relates to N-deacetyl-lysogangliosides and physiologically acceptable salts thereof, especially those of formula (I): <CHEM> wherein R represents -CH=CH(CH2)nCH3 or -CH2CH2(CH2)nCH3; n is 12 or 14; R<1> represents <CHEM> <CHEM> or hydrogen; and R<2> represents hydrogen or acetyl; for use in therapy. The compounds are useful as inhibitors of phospholipases A2, and of superoxide production, as antiproliferative and immunosuppressant agents and in the treatment of autoimmune diseases. The invention also relates to the use of N-deacetyl-lysogangliosides for the manufacture of medicaments for the treatment of the aforementioned conditions.</p> |
申请公布号 |
EP0438921(A1) |
申请公布日期 |
1991.07.31 |
申请号 |
EP19900314355 |
申请日期 |
1990.12.27 |
申请人 |
THE WELLCOME FOUNDATION LIMITED |
发明人 |
TUBARO, EZIO;CAVALLO, GIOVANNI |
分类号 |
H04N5/7826;A61K31/70;A61K31/7028;A61P3/00;A61P35/00;A61P37/06;A61P43/00;C07H15/10;G04G15/00;G11B15/02;H01H9/02;H04N5/00;H04N5/44;H04N5/76;H04N5/761;H04N5/7613;H04N5/7617;H04N5/765;H04N5/782;H04Q9/00 |
主分类号 |
H04N5/7826 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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