1-Phenylalkyl-3-phenylurea derivative.

摘要

A novel 1-phenylalkyl-3-phenylurea derivative represented by the following formula (I): <CHEM> wherein R<1> and R<6> represent independently hydrogen, C1-C5 alkyl, C1-C5 alkoxyl or halo; R<2> represents hydrogen or C1-C15 alkyl; R<3> represents C1-C15 alkyl or R<3> represents together with R<2> C2-C9 alkylene; R<4> and R<5> represent independently C1-C5 alkyl, C1-C5 alkoxyl or halo; X represents oxygen or sulfur; Y represents -O-(CH2) l -O- wherein l is an integer of 1 to 3 or -(CH2)p- wherein p is an integer of 3 to 5; m is 0 or an integer of 1 to 5; and n is 0 or an integer of 1 to 3, is provided. The 1-phenylalkyl-3-phenylurea derivative (I) have the action of reducing cholesterol in blood by ACAT inhibition, and therefore, useful for treating hyperlipemia and atherosclerosis.