| 摘要 |
<p>NEW MATERIAL:A compound expressed by formula I [R<1> is (substituted) phenyl; R<2> is H or lower alkyl; R<3> is COOR<4> (R<4> is lower alkyl), COR<4>, SO2R<4> or CONHR<5> (R<5> is H or lower alkyl); (n) is 1 or 2]. EXAMPLE:A compound expressed by formula II. USE:An antibacterial agent against Gram-positive and Gram-negative bacterial, especially the Gram-negative bacterial. PREPARATION:A ylide compound expressed by formula III (R<6> is alkyl or phenyl; P<1> and P<2> are amino or carboxy-protecting group) is made to react with an aldehyde compound expressed by formula IV to provide a compound expressed by formula V, which is then deprotected.</p> |
