Improvements in and relating to angiotensin II antagonists.

摘要

This invention provides phenyl and heterocyclic derivatives of the formula <CHEM> or a pharmaceutically acceptable salt or solvate thereof <CHEM> each of A1, A2, and A3 is independently N or CH; X is -CO-, -CONH-, -NHCO-, -CH2 CONH-, -O-, -NH-, -CH2-each R1 is independently - (CH2)nR3; R2 is C4-C7 straight chain alkyl; each R3 is independently -OH, -COOH, or 5-tetrazolyl; each n is independently 0, 1, 2, 3, or 4; R4 is H, OH, halo, nitro, methyl, amino, acetamido, or methanesulfonamido; Q is a bond or -O-; and w is H, methyl, ethyl, or hydroxy. Their pharmaceutical formulations and their use for antagonizing angiotensin II receptors in mammals.