发明名称 |
PROCESS FOR THE PRODUCTION OF 3-(1-AMINO-1,3-DICARBOXY-3- HYDROXY-BUT -4-YL)INDOLE |
摘要 |
The invention provides a process for the production of 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl) indole and certain salts and internal condensation products thereof. An unsaturated indolyl ester is reacted with ethylchloro(hydroxyimino)acetate in the presence of triethylamine in an organic solvent to cause a 1,3- dipolar addition reaction to form a di-ester. The di-ester is saponified to form a di-acid which di-acid is then reduced to form either the product indole or a salt thereof. |
申请公布号 |
AU6981091(A) |
申请公布日期 |
1991.07.25 |
申请号 |
AU19910069810 |
申请日期 |
1991.01.21 |
申请人 |
TECHNOLOGY FINANCE CORPORATION (PROPRIETARY) LIMITED |
发明人 |
JOHAN OLIVIER;KARL BISCHOFBERGER |
分类号 |
C07D209/20;C07D261/04;C07D403/06;C07D405/06 |
主分类号 |
C07D209/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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