| 摘要 |
<p>A muscarinic receptor antagonist of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is N or (a) where R4 is H, halo or C¿1?-C4 alkyl; R?1¿ is H or C¿1?-C4 alkyl; R?2¿ is H or C¿1?-C4 alkyl; Y is a direct link, O or S; m is an integer of from 1 to 4; n is 2 or 3; and R?3¿ is 1- or 2-naphthyl or a group of formula (b), (c) or Het where R?5 and R6¿ are each independently H, C¿1?-C4 alkyl, C1-C4 alkoxy, -(CH2)qOH, halo, trifluoromethyl, cyano, -(CH2)qNR?7R8¿, -OCO(C¿1?-C4 alkyl), -SO2NH2 or -CONR?9R10¿; where either R?7 and R8¿ are each independently H or C¿1?-C4 alkyl, or R?7¿ is H and R8 is -SO¿2?(C1-C4 alkyl), -CONR?9R10¿, -CO(C¿1?C4 alkyl) or -SO2NH2; R?9 and R10¿ are each independently H or C¿1?-C4 alkyl; q is 0, 1 or 2; Z and Z?1¿ are each independently O or CH¿2?; p is 1, 2 or 3; and ''Het'' is pyridyl, pyrazinyl or thienyl. The compounds are particularly useful in the treatment of irritable bowel syndrome.</p> |
