| 摘要 |
<p>Anthracycline anti-neoplastic agents are formulated in phospholipid micellular particles. In a preferred embodiment, the particles are in the form of vesicles which comprise an anthracycline agent, preferably daunorubicin, distearyl phosphatidyl choline, distearyl phosphatidyl glycerol and cholesterol, preferably in a molar ratio of about 1:2:0:0 to about 1:4:20:20. The vesicles are suspended in a low ionic solution such as 5% dextrose at pH 7.4.</p> |
