| 摘要 |
NEW MATERIAL:A penicillin compound of formulaI[R is H or (acylated) OH; -COOR' is (esterified) carboxyl; R1 and R2 are H or lower alkyl]. EXAMPLE:6-[D-(-)-alpha-{[2-Oxo-3-(1,3-dithiolane-2-imino)-imidazolidin -1-yl]-carboxamido}-alpha-phenylacetamido]-penicillanic acid. USE:It has excellent antibacterial activity against a wide variety of pathogenic bacteria such as Gram-negative bacteria, Gram-positive bacteria, etc. including Pseudomonas aeruginosa, and is useful for the prevention and remedy of diseases caused by the pathogenic bacteria. PROCESS:The compound of formulaIis prepared by reacting the compound of formula II with the compound of formula III or its reactive derivative in a solvent such as water, at a low temperature, i.e. -50-+30 deg.C. The compound of formula III used as a raw material is novel compound. |
