Substituted 1,8-naphthyridines and their use in medicaments

摘要

Inhibitors of 3-hydrooxy-3-methyl-glutarylcoenzyme A reductase which are 1,8-naphthyridines of the formula <IMAGE> in which A represents a 3- to 7-membered heterocycle which is optionally substituted, or aryl which is optionally substituted, B represents cycloalkyl or alkyl which is optionally substituted, aryl which is optionally substituted, D and E are identical or different and represents hydrogen, halogen, mercapto, hydroxyl, alkoxy, alkyl which is optionally substituted, or a group of the formula -NR1R2, aryl, aryloxy or arylthio having 6 to 10 carbon atoms, which is optionally substituted, Y represents a group of the formula <IMAGE> in which J denotes hydrogen, hydroxyl, mercapto or halogen, or alkyl, alkoxy or alkylthio which are optionally substituted, aryloxy, benzyloxy or arylthio or a group of the formula -NR1R2, Z denotes oxygen or sulphur, G denotes hydrogen, alkyl or alkenyl which is optionally substituted, X represents a group of the formula -CH2-CH2- or -CH=CH-, and R represents a group of the formula <IMAGE> in which R5 denotes hydrogen or alkyl, and R6 denotes hydrogen or alkyl, which may be substituted by phenyl, or denotes aryl or a cation, and their salts.