| 摘要 |
Novel compounds of formula (I), and pharmaceutically acceptable salts thereof; their preparation; compositions containing them; and their use in the treatment of conditions in which degradation of connective tissue and other proteinaceous components of the body occurs: <CHEM> in which, R1 is -OH; alkoxy; aryloxy or aralkyloxy in each of which the aryl group is optionally substituted; -NR6R7, where each of R6 and R7 is independently hydrogen or alkyl, or R6 and R7 together with the nitrogen atom to which they are bonded form a 5-, 6- or 7-membered ring with an optional oxygen or sulphur atom or an optionally substituted second nitrogen atom in the ring; or a group: -NH-CH(R8)-C(O)-R9 where R8 is hydrogen; alkyl optionally substituted by -OH, alkoxy, -NR6R7 as defined for R1, guanidine, -CO2H, -CONH2, -SH, or -S-alkyl; or -CH2-Ar where Ar is optionally substituted aryl or heteroaryl; and R9 is alkoxy; -OH; or -NR6R7 as defined for R1; R2 is hydrogen; C2-8 alkanoyl; or optionally substituted aroyl; R3 is C3-6 alkyl; and R4 is -(CH2)m- where m is an integer from 4 to 12. |
