1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE FOR THE REMOVAL OF TOXIC METAL IONS AND RADIOACTIVE ISOTOPES FROM THE LIVING ORGANISM

摘要

1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE DERIVATIVES PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE FOR THE DECORPORATION OF METAL IONS, MAINLY RADIOACTIVE ISOTOPES DAMAGING THE LIVING ORGANISM The invention relates to partially novel metal complexes, salts and double salts of 1,4,10,13-tetraoxa-7,16-diazacycloocta-decane compounds of the formula (I), (I) wherein Q1 and Q2 mean hydrogen or a group of the formula (III), (III) in the groups of the formula (III) the R subtituents independently represent hydroyen, a C1_5 straight or branched chain alkyl group, a C2-5 straight or branched chain alkenyl group, phenyl or phenyl-C1-5alkyl group, the two latter ones optionally being substituted on their aromatic part by one or more halogen(s), C1-5alkyl, C1-5alk-oxy, cyano or nitro group(s), with the proviso that at least one of Q1 and Q2 is other than hydrogen; Me stands for an alkaline metal or alkaline earth metal or transition metal ion; q is 0 or 1; M and N, independently from each other, stand for hydrogen or an alkaline metal, alkaline earth metal or optionally substituted ammonium ion; m, n and p are integers each being equal to the charge of M, N or Me, respectively; s and r are, independently from each other, O, 1, 2, 3 or with the proviso that (i) r, s and q cannot simultaneously be 0; and (ii) the number of hydrogens in the meaning of M or N may be 0, 1 or 2, as well as pharmaceutical compositions containing these compounds. The compounds and compositions according to the invention can be used for the decorporation of metal ions, mainly radioactive isotopes such as radioactive strontium or cerium being harmful to the living organism. The active agents according to the invention exert their effects either in intravenous or local, transdermal or rectal route of administration.