发明名称 |
3-hydroxy-N-methylpyrrolidone and use as transdermal enhancer |
摘要 |
The novel compound, 3-hydroxy-N-methylpyrrolidone, is effective as a transdermal enhancer for the absorption of drugs through the skin of humans and animals. The 3-hydroxy-N-methylpyrrolidone is prepared from delta-butyrolactone which is converted to methyl 2,4-dibromobutyrate, this intermediate is reacted with methylamine to form N-methyl-2,4-dibromobutyramide, this intermediate is converted to 3-bromo-N-methyl-2-pyrrolidone by ring closure, and the 3-bromo-N-methyl-2-pyrrolidone is reacted with an alkaline earth metal carbonate or alkaline metal carbonate to form 3-hydroxy-N-methyl-2-pyrrolidone.
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申请公布号 |
US5032402(A) |
申请公布日期 |
1991.07.16 |
申请号 |
US19900554501 |
申请日期 |
1990.07.19 |
申请人 |
THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION |
发明人 |
DIGENIS, GEORGE A.;DOLL, WALTER J.;HAWI, AMALE |
分类号 |
A61K47/22;C07D207/26;C07D207/273 |
主分类号 |
A61K47/22 |
代理机构 |
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地址 |
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