| 摘要 |
There are disclosed novel compounds of the formula <IMAGE> where n is 0 or 1; R is hydrogen or loweralkyl; R1 is hydrogen, loweralkyl, halogen, cyano, loweralkanoyl, arylloweralkanoyl, aroyl, -CH(OH)R4, -C(OH)R4R5 or -CH2OR5, -CH=CR6R7, -CH=CHCN, -CH=CHOCH3, -CH=CHCO2C2H5, <IMAGE> <IMAGE> <IMAGE> CH2CH2OCH3, CH2CH2CO2C2H5, <IMAGE> <IMAGE> <IMAGE> R4 being hydrogen, loweralkyl, arylloweralkyl or aryl, R5 being loweralkyl, aryl or arylloweralkyl, R6 being hydrogen or loweralkyl and R7 being hydrogen, loweralkyl or aryl; R2 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, -CH2CO2C2H5, arylloweralkyl, phenyl, nitrophenyl, cyanophenyl, trifluoromethylphenyl, aminophenyl, loweralkanoylaminophenyl, loweralkoxycarbonyl, arylloweralkoxycarbonyl, aryloxycarbonyl, loweralkylaminocarbonyl, arylloweralkylaminocarbonyl, arylaminocarbonyl, alkanoyl, arylloweralkanoyl, aroyl, alkenoyl, alkynoyl, -CH2C 3BOND CCH2-NR'R'', -CH2CH=CHCH2-NR'R'' or -CH2CH2CH2CH2-NR'R'', R' and R'' being independently loweralkyl or -NR'R'' taken as a whole being <IMAGE> and R3 is hydrogen, NO2, NH2, halogen, loweralkanoylamino, arylloweralkanoylamino, aroylamino or loweralkyl; with the proviso that when n is 0, R2 is phenyl, R3 is hydrogen and the pyridine moiety is 2-pyridinyl, R and R1 may not be 2-methyl and 5-methyl; or pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory, methods for synthesizing them, pharmaceutical compositions comprising an effective memory enhancing amount of such a compound and a method of treating a patient in need of memory enhancement which comprises administering such a compound to the patient.
|
