发明名称 |
Method for treating fungal infections with amphotericin B/cholesterol sulfate composition |
摘要 |
An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 1:4. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes predominantly between aobut 100-400 nm. The composition formed at a molar ratio of about 1:1 amphotericin B:cholesterol sulfate has stable particle sizes in an aqueous suspension over a several-day storage period. The composition is significantly less toxic and more effective in treating fungal infections than prior amphotericin B formulations.
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申请公布号 |
US5032582(A) |
申请公布日期 |
1991.07.16 |
申请号 |
US19890320354 |
申请日期 |
1989.03.08 |
申请人 |
LIPOSOME TECHNOLOGY, INC. |
发明人 |
ABRA, ROBERT |
分类号 |
A61K9/00;A61K9/51;A61K47/28 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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