发明名称 |
LIPOPROTEIN SIGNAL PEPTIDE FUSED TO ANTIGENIC POLYPEPTIDES |
摘要 |
The present invention relates to a fusion plasmid for in vivo synthesis of a lipid modified polypeptide. The plasmid comprises a first DNA sequence encoding a lipoprotein signal peptide, preferably a bacterial lipoprotein signal peptide, and at least the first amino acid of a mature lipoprotein, preferably cysteine. In the DNA sequence, the preferred cysteine codon may be followed by codons for a few amino acids forming a beta -turn structure. These amino acids may also include a specific exogenous protease recognition cleavage site. A second DNA sequence encoding the desired polypeptide can be inserted into the fusion plasmid to produce the desired lipid modified polypeptide. |
申请公布号 |
WO9109952(A1) |
申请公布日期 |
1991.07.11 |
申请号 |
WO1990CA00460 |
申请日期 |
1990.12.27 |
申请人 |
MAJESTY (HER) IN RIGHT OF CANADA AS REPRESENTED BY |
发明人 |
LAU, PETER;RIOUX, CLEMENT |
分类号 |
C07K1/107;C07K14/485;C12N15/62;C12N15/70 |
主分类号 |
C07K1/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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