| 发明名称 |
TARGET-SPECIFIC, CYTOTOXIC, RECOMBINANT PSEUDOMONAS EXOTOXIN |
| 摘要 |
A target-specific, cytotoxic, recombinant Pseudomonas exotoxin is described. Such toxins are made by inserting specific recognition molecules at specific cloning sites in at least domain III at the carboxyl terminus of the PE molecule. Various modifications of the carboxyl terminus of the PE molecule to increase cytotoxicity are set forth. |
| 申请公布号 |
WO9109949(A1) |
申请公布日期 |
1991.07.11 |
| 申请号 |
WO1990US07421 |
申请日期 |
1990.12.27 |
| 申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY TH |
发明人 |
PASTAN, IRA;CHAUDHARY, VIJAY;FITZGERALD, DAVID |
| 分类号 |
A61K38/00;A61P35/00;C07K14/00;C07K14/21;C07K14/495;C07K14/73;C07K16/28;C07K19/00;C12N15/09;C12N15/31;C12P21/02;C12R1/19;C12R1/38 |
主分类号 |
A61K38/00 |
| 代理机构 |
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代理人 |
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| 地址 |
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