发明名称 |
PHOTODYNAMIC VIRAL DEACTIVATION WITH SAPPHYRINS |
摘要 |
The present invention demonstrates a method of photodynamic inactivation of viruses having a membranous envelope, such as Herpes simplex type 1 and Human immunodeficiency type 1 viruses. The method uses substituted sapphyrin compounds to effect viral deactivation during irradiation with light at or near the absorption wavelength of the sapphyrin compound. A highly reactive species selectively toxic to infectious agents is produced. One particular sapphyrin compound useful for the practice of the invention is 8,17-bis(carboxymethyl)-3,12,13,22-tetraethyl-2,7,18,23-tetramethylsap phyrin (Sapphyrin 2). The most preferred sapphyrin compound for the practice of the invention is 3,8,12,13,17,22-hexaethyl-2,7,18,23-tetramethylsapphyrin (Sapphyrin 1). The method is particularly suitable for inactivation of viruses in blood and blood products. |
申请公布号 |
WO9109631(A2) |
申请公布日期 |
1991.07.11 |
申请号 |
WO1990US07610 |
申请日期 |
1990.12.21 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;BAYLOR RESEARCH FOUNDATION |
发明人 |
MATTHEWS, J., LESTER;NEWMAN, JOSEPH, T.;SOGANDARES-BERNAL, FRANK;SESSLER, JONATHAN, L.;HARRIMAN, ANTHONY;MAIYA, BHASKAR, G.;JUDY, MILLARD, M. |
分类号 |
A61K41/00;A61L2/00;C07D487/22 |
主分类号 |
A61K41/00 |
代理机构 |
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