发明名称 PHTHALIDE DERIVATIVE AND CELL KILLING AGENT OF CERVICAL CARCINOMA CELL CONTAINING SAME DERIVATIVE AS ACTIVE INGREDIENT
摘要 NEW MATERIAL:6-[2' E)-3',7'-Dimethyl-5'-oxo-2',6'-octadienyl]-7-hydroxy-5- methoxyphthalide expressed by the formula. USE:A cell-killing agent of cervical carcinoma cell. PREPARATION:A fruit body of Hericium erinaceum is subjected to extraction treatment with a homogeneous system consisting of water and an organic solvent (e.g. methanol or acetone) and the organic solvent is evaporated from the extracted liquid subjected to solid-liquid separation by filtration, etc., to afford a water phase. An organic solvent layer is collected by subjecting the water phase to liquid distribution treatment with a mixed system of water and organic solvent and the organic solvent is evaporated from the organic solvent layer to give the dried material. The dried material is subjected to chromatography fraction treatment and recrystallization treatment.
申请公布号 JPH03157379(A) 申请公布日期 1991.07.05
申请号 JP19890295449 申请日期 1989.11.14
申请人 KAGOME KK 发明人 MIZUNO TAKU;KAWAGISHI HIROKAZU;SUEDA TAKASHI;YOSHIDA TOMOSHI;SUZUKI CHIHARU
分类号 C07D307/88;A61K31/365;A61K36/07;A61P35/00 主分类号 C07D307/88
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