发明名称 Bis(aryl)alkene compounds
摘要 The invention relates to compounds of formula I: <IMAGE> (I) in which m=2-4, n and p, which may be identical or different, are an integer equal to 1, 2 or 3, with the proviso that the sum of n and p is not less than 3 and not more than 5, q=0 or 1, R is a 1,2,3,4-tetrahydro-3-quinazolinyl radical, optionally substituted, a 1,3,4,6,11,11a-hexahydro-1,3-dioxo-2H-pyrazino[1,2,-b]isoquinol-2-yl radical, a 1,2-dihydro-1-oxo-2-phthalazinyl radical, optionally substituted, a 2,6-dioxo-1-piperazinyl radical of formula W: <IMAGE> (W) (R3 is a 2-pyridyl radical or an optionally substituted phenyl radical), a radical of formula Z: <IMAGE> (Z) (R4is a carbamoyl radical, a cyano radical, a hydroxycarbonyl radical or an alkoxycarbonyl radical having 1 to 6 carbon atms), or a radical of formula Y: <IMAGE> (Y) (R5 is a 2-pyrimidinyl radical, a 1-isoquinolyl radical, a 2-quinolyl radical, a 2-pyridyl radical, a benzyl radical, optionally substituted, a 2-thiazolyl radical, optionally substituted, or a 2-benzothiazolyl radical) and either R1 and R2, identical or different, each are a substituted phenyl radical, or R1 is a phenyl radical and R2 a 2-pyridyl radical (it being possible for each of these two radicals to be substituted), or R1 and R2, together with the carbon atom to which they are attached, form a fluorene radical. Medicinal products
申请公布号 US5028607(A) 申请公布日期 1991.07.02
申请号 US19900460751 申请日期 1990.01.04
申请人 ADIR ET COMPAGNIE 发明人 LAVIELLE, GILBERT;COLPAERT, FRANCIS;LAUOIE, MICHEL
分类号 A61K31/495;A61K31/50;A61K31/505;A61K31/55;A61P27/16;A61P37/08;A61P43/00;C07D207/08;C07D211/18;C07D223/04;C07D401/06;C07D401/14;C07D403/06;C07D417/12;C07D471/04;C07D487/04 主分类号 A61K31/495
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