PROCESS FOR THE PREPARATION OF STABILIZED ISOSORBIDE- 5-MONONITRATE TABLETS, BEING ALSO OF SUSTAINED RELEASE, AND FORMULATIONS THUS OBTAINED

摘要

The present invention relates to obtaining isosorbide-5-mononitrate tablets, being also of retard form, which are stable in time. Such embodiment is now possible after the discovery of the stabilizing activity of the polyvinylpyrrolidone with respect to the isosorbide-5-mononitrate with which it forms a solid solution. The use of PVP is essential so that the tablets can remain stable in time: the retard effect in turn can be obtained with the use of hydroxyalkylcelluloses.