发明名称 |
FOERFARANDE FOER BESTAEMNING AV TOTALDIGOXINHALTERNA. |
摘要 |
A method for determining total digoxin levels in a biological fluid sample containing digoxin-protein complex which method comprises disrupting the digoxin-protein complex by treating said sample solution with an effective amount of a dissociation agent selected from one or more members of the group consisting of a C3-C26 saturated or unsaturated fatty acid, a C2-7 lower alkanol, quinidine and alpha -tocopherol so as to release the bound digoxin from serum protein, passing the treated sample solution through a centrifugal ultrafilter so as to selectively pass digoxin containing sample solution through said filter and retaining said serum proteins and determining the digoxin contents in said sample solution in a fluorescence polarization assay. A kit for carrying out the method is provided. |
申请公布号 |
FI84106(B) |
申请公布日期 |
1991.06.28 |
申请号 |
FI19860001568 |
申请日期 |
1986.04.14 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
FARRENKOPF, BRUCE C.;KAUFMAN, RICHARD A. |
分类号 |
G01N33/52;G01N21/76;G01N21/77;G01N21/78;G01N33/53;G01N33/542;G01N33/543;G01N33/94;(IPC1-7):G01N33/53 |
主分类号 |
G01N33/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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