NOVEL 1,4-DIHYDROPYRIDINES CONTAINING FLUORINE, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

摘要

Hypotensive long-acting 1,4-dihydropyridines of the formula in which R1 is phenyl or heterocyclic, R2, R3, R4 and R5 have the usual definitions in such compounds, R6 represents hydrogen or a lower alkyl radical or the trifluoromethyl group, R7 and R8 each denote a hydrogen atom or a fluorine atom, n>/=1 and m>/=0, and the sum of n and m must be a least 4, and X represents a single bond, an oxygen atom or the group -N(alkyl)-O2S-, or pharmacologically acceptable acid addition salts thereof.