| 摘要 |
<p>The invention comprises esters of 2,6- and 2,7 - di - tertiary-butyl-naphthalene-4-sulphonic acid and mixtures thereof. Esters are preferably alkyl, cycloalkyl, aryl, aralkyl esters or those derived from ethylene glycol or glycerol. The esters are prepared by reacting the sulphonyl chloride with a compound containing a reactive hydroxy group or for lower alkyl esters, the sulphonic acid with a diazo paraffin or an ester of a polybasic inorganic acid. 2,6- and 2,7-Di-tertiary-butylnaphthalene-4-sulphonic acids are prepared by reacting the appropriate hydrocarbon with chlorosulphonic acid and further reaction with thionyl chloride yields the acid chlorides. Antitussive compositions comprise the esters or mixtures thereof and a pharmaceutical vehicle and may be formulated as tablets.</p> |
